Dr. Healy was born in NewCastle West, Co. Limerick Ireland, and received a doctorate in chemistry in 1984 from the University of Texas at Austin where he was a student of Dr. Michael J. S. Dewar. As a member of the Dewar research group he co-authored Austin Model 1, or AM1, a semi-empirical method for the quantum calculation of molecular electronic structure in computational chemistry. He has authored over 50 peer-reviewed publications, and appears in Richard Linklater's 2001 film Waking Life discussing concepts similar to a technological singularity and explaining "telescopic" and technological evolution (http://en.wikipedia.org/wiki/Eamonn_Healy ).
My overall teaching philosophy is to convey to my students the sense of excitement and wonder that I feel in dealing with my discipline, and for them to leave with an ability to reason and critically evaluate the information and concepts presented to them.
The general focus of my research involves the use of molecular modeling to design structure-activity probes for the purpose of elucidating enzymatic activity. Recent targets have included HIV-1 integrase, the c-Kit and src-abl proteins associated with tumor development and certain leukemias, and the metalloproteinases associated with the shedding of chemokine CXCL16. For the latter work we have used ligand-protein docking to guide and characterize in vitro assays of CXCL16 shedding. We have also investigated the bacterial and host contributions to latent Mtb infection through the identification of the macrophage cellular responses that are modulated by the Mtb alpha-crystallin (Acr) protein. This work has allowed for an in silico characterization of the mechanism of action of Mtb Acr, that in turn has led us to a novel mechanism of action for all small Heat Shock Proteins (sHSP). More recently we have expanded this analysis to characterize mechanistic details for the heat shock response of Escherichia coli, and we have developed a model to explain the observed suppression of spinocerebellar ataxia by human alphaB-crystallin through the formation of a transient complex. A transient, non-obligate oligomer model has also been developed to explain aspects of the etiology of Amyotrophic Lateral Sclerosis or ALS.
Peer-reviewed publications († student author):
Healy, E.F., Rowland, C. †, Topological Analysis of the Electron Density of Molecules with Bridging Hydrogens to Tackle the Chemical Structure Monolith, European Journal of Inorganic Chemistry 2022, 34, e202200538.
Healy, E.F., "How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17" Biochem. Biophys. Res. Commun. 2022,593, 52-56.
Healy, E.F., Lilic, M. †, "A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17" Biochem. Biophys. Res. Commun. 2021 in press .
Eamonn F Healy, Lisa M. Goering, Charles R. Hauser, and Peter J. King “An immunomodulatory role for the Mtb Acr protein in the formation of the tuberculous granuloma” FEBS Lett.. 2021, 595, 284-293.
Eamonn F Healy, Organic chemistry as representation Foundations of Chemistry, 2021 23, 59-68.
Healy, E. F., & Blade, G. † “Tips and Tools for Teaching Organic Synthesis Online” Journal of Chemical Education, 2020, 97, 3163–3167.
Healy, Eamonn F., Rafael Flores†, Vincent M. Lynch, and Santiago Toledo. "Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1." Journal of Inorganic Biochemistry 2020, 210, 111161.
Eamonn F. Healy. "Reply to Comment on “Should Organic Chemistry Be Taught as Science?”", Journal of Chemical Education 2020, 97, 1215-1215.
Eamonn F Healy, Analise Roth-Rodriguez† and Santiago Toledo “A model for gain of function in superoxide dismutase” Biochem. Biophys. Rep. 2020, 21, 100728.
Eamonn F Healy, Should Organic Chemistry be taught as Science ?, Journal of Chemical Education, 2019 , 96, 10, 2069-2071
Eamonn F Healy, Luis Cervantes†, Barret Nabona†, Jacob Williams†, "A unified mechanism for plant polyketide biosynthesis derived from in silico modeling", Biochemical and Biophysical Research Communications, 2018, 497, 1123-1128..
E.F. Healy, “Visualizing the molecular wave function in sigma-coordinated complexes”, Computational and Theoretical Chemistry, 2018,1125, 128-132.
Eamonn F. Healy “A prion-like mechanism for the propagated misfolding of SOD1 ”, PLoS ONE 2017, 12 (5), e0177284.
† student author
Healy, E. F., 2019 A mechanism for coupled gain of structure and loss of function in amyotrophic lateral sclerosis.12th EBSA 10th ICBP-IUPAP Congress Madrid, Spain, July EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Vol. 48, pp. S143-S143). 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.
Healy, E.F., 2017 A Prion-like mechanism in Amyotrophic Lateral Sclerosis. 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress Edinburgh, Scotland, July EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Vol. 46, pp. S217-S217). 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.SPRINGER.
Protein dynamics in Superoxide Dismutase (SOD1) Cervantes, L., & Healy, E. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253 2017.
"Structural Ontology and Chemical Epistemology:The case of the pi-complex" Eamonn F Healy, presented at the International Society for the Philosophy of Chemistry - Summer Symposium , Boca Raton, 2016.
Telescopic Evolution (from the movie "Waking Life)
Account of presentation at the 251st ACS National Meeting & Exposition in San Diego, Spring, 2016, titled "Between two stools: Pauling, Mulliken, and Michael J. S. Dewar"
Account of paper titled "Visualizing the molecular wave function in s-coordinated complexes"
Classes Taught Fall/Spring: